Sophia Santiago has performed as a soloist across the New York metropolitan area. She studied with Faith Esham at Westminster Choir College; performing Mozart opera roles Pamina from die Zauberflöte and Susanna from Le nozze di Figaro. Her Master’s Degree in Vocal Performance was completed at Manhattan School of Music with Shirley Close where she specialized in contemporary music preparation. 

Sophia won first place at the Spazio e Musica competition in 2022 and performed a concert series across Italy with early music ensemble I Musicalli Affetti. She was a New York District winner in the Laffont competition of 2022 and studied at the 2023 American Bach Soloist Academy. In 2024, she sang in the Hugo Wolf Akademie Liedduo Competition in Stuttgart, Germany. Sophia was the soprano soloist in Caldara’s Missa dolorosa with the Mendelssohn Chorus of Philadelphia with which she also performed as Belinda in Purcell’s Dido and Aeneas in 2025.

Recent engagements in the 2025-2026 season include her solo debut with Opera Philadelphia as a Godmother in the world premier of Sleeper’s Awake by Gregory Spears. She performed as soloist with VAE in Cincinnati, Ohio in Buxtehude’s Membra Jesu nostri and performed Bach's Jauchzet in allen landen with the West Jersey Chamber Ensemble.